Description

Eserine Sulfate is a high-purity, crystalline salt form of the alkaloid physostigmine, widely recognized for its potent acetylcholinesterase inhibitory activity. This compound is critical for research and development in neuropharmacology, serving as a key reference standard and active pharmaceutical ingredient. It is essential for scientists and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require a reliable, high-quality compound for neurological research, drug discovery, and the formulation of specialized ophthalmic solutions.

Application

• Pharmaceutical Reference Standard: Used as a primary standard in analytical methods (HPLC, LC-MS) for quality control and assay validation of related pharmaceutical products.
• Neurological Research: A vital tool in preclinical studies investigating cholinergic pathways, Alzheimer's disease, myasthenia gravis, and other neurodegenerative conditions.
• Ophthalmic Drug Formulation: Employed in the development and production of miotic agents for the treatment of glaucoma, helping to reduce intraocular pressure.
• Biochemical Assay Development: Acts as a specific inhibitor of acetylcholinesterase in enzymatic assays to study enzyme kinetics and screen for new inhibitors.
• Antidote Research: Investigated for its potential as a counteragent in cases of anticholinergic poisoning or drug overdose.
• Academic & Contract Research: Supplied to universities and CROs for fundamental pharmacological research and toxicology studies.

Basic Information

Product Name	Eserine Sulfate
CAS No.	64-47-1
Molecular Formula	C29H38N4O8S
Molecular Weight	602.70 g/mol
Synonyms	Physostigmine Sulfate; Eserine Sulphate; Physostigmine Sulphate; (3aS,8aR)-1,3a,8-Trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl N,N-dimethylcarbamate sulfate (1:1); Physostol; Antilirium; Isopto-Eserine
EINECS	200-589-7

Quality Control

Our Eserine Sulfate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent control of residual solvents and heavy metals. We provide Certificates of Analysis (COA) with each shipment, detailing all test results against relevant pharmacopeial standards (e.g., USP, EP) where applicable, ensuring reliable consistency and traceability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.