Description

Morpholine, 3,5-Dimethyl-, (3R,5R)- CAS NO 591779-91-8 is a chiral, substituted morpholine derivative characterized by its specific stereochemistry at the 3 and 5 positions. This compound is a valuable chiral building block and intermediate in the synthesis of complex molecules, particularly in the pharmaceutical industry where stereochemical purity is critical. It is primarily utilized by research chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials that require precise three-dimensional structure.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Catalyst Ligand Precursor: Serves as a starting material for the preparation of chiral ligands used in asymmetric catalysis (e.g., hydrogenation, cross-coupling).
• Advanced Material Research: Employed in the synthesis of chiral ionic liquids, polymers, and liquid crystals with specific optical properties.
• Organic Synthesis Building Block: Utilized in academic and industrial R&D for constructing complex nitrogen- and oxygen-containing heterocycles.

Basic Information

Product Name	Morpholine, 3,5-Dimethyl-, (3R,5R)-
CAS No.	591779-91-8
Molecular Formula	C6H13NO2
Molecular Weight	131.17 g/mol
Synonyms	(3R,5R)-3,5-Dimethylmorpholine; (3R,5R)-3,5-Dimethyltetrahydro-1,4-oxazine; (3R,5R)-3,5-Dimethylmorpholine; (R,R)-3,5-Dimethylmorpholine; cis-3,5-Dimethylmorpholine; 1,4-Oxazine, tetrahydro-3,5-dimethyl-, (3R,5R)-; Chiral 3,5-dimethylmorpholine
EINECS	Contact for details

Quality Control

Our chiral intermediates are produced under strict quality control protocols to ensure high chemical and enantiomeric purity. Each batch is characterized using advanced analytical techniques including chiral HPLC, GC, NMR, and optical rotation measurement. Certificates of Analysis (COA) are provided with each shipment, detailing assay, enantiomeric excess (ee), and impurity profiles. We support development and commercial projects requiring compliance with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient humidity. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.