Description

(5-(Cyclopropylcarbamoyl)-3-Fluoro-2-Methylphenyl)Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and Suzuki-Miyaura cross-coupling reagent. This compound is critical for constructing complex molecular architectures, particularly in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for introducing the boronic ester functional group with high selectivity and yield.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile organoboron reagent for forming carbon-carbon bonds between aromatic rings, a fundamental reaction in modern medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific aryl-boronate motifs.
• Material Science Research: Employed in the development of organic electronic materials, such as polymers for OLEDs and OFETs, where precise molecular structure is paramount.
• Chemical Biology & Proteomics: Can be utilized as a probe or linker in bioconjugation strategies and the development of chemical tools.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of client-specific molecules.

Basic Information

Product Name	(5-(Cyclopropylcarbamoyl)-3-Fluoro-2-Methylphenyl)Boronic Acid Pinacol Ester
CAS No.	585544-29-2
Molecular Formula	C₁₈H₂₅BFNO₃
Molecular Weight	333.21 g/mol
Synonyms	5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylbenzeneboronic acid pinacol ester; (3-Fluoro-5-[(cyclopropylamino)carbonyl]-2-methylphenyl)boronic acid pinacol ester; (5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl)boronic acid pinanediol ester (common alternate naming); B-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Boronic acid, B-[5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; 585544-29-2 (CAS Registry Number); Pinacol (5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl)boronate
EINECS	Contact for details

Quality Control

Our (5-(Cyclopropylcarbamoyl)-3-Fluoro-2-Methylphenyl)Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance in sensitive cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maximize shelf-life stability, as boronic esters can be sensitive to prolonged exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.