Description

3-Bromo-4-(Trifluoromethyl)Benzoic Acid is a high-value, multi-functional aromatic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for introducing specific steric and electronic properties into target molecules, enabling the development of advanced materials and active pharmaceutical ingredients. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for use in cross-coupling reactions, ligand synthesis, and as a precursor for more complex derivatives.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used as a precursor for creating advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to construct complex biaryl systems.
• Ligand and Catalyst Development: Utilized to synthesize novel chelating ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Research: A versatile reagent in academic and industrial R&D for exploring new synthetic methodologies and constructing molecular libraries.

Basic Information

Product Name	3-Bromo-4-(Trifluoromethyl)Benzoic Acid
CAS No.	581813-17-4
Molecular Formula	C8H4BrF3O2
Molecular Weight	269.02 g/mol
Synonyms	3-Bromo-4-(trifluoromethyl)benzoic acid; Benzoic acid, 3-bromo-4-(trifluoromethyl)-; 4-Trifluoromethyl-3-bromobenzoic acid; 3-Bromo-α,α,α-trifluoro-p-toluic acid; 3-Bromo-4-trifluoromethylbenzoic acid; 3-Br-4-CF3-BA; 581813-17-4 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-4-(Trifluoromethyl)Benzoic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.