Description

Topiroxostat is a potent, selective, and non-purine xanthine oxidase inhibitor used as an active pharmaceutical ingredient (API). This compound is critical for the development and manufacture of urate-lowering therapies, offering a targeted mechanism of action for managing conditions like hyperuricemia and gout. It is essential for pharmaceutical manufacturers and research institutions focused on metabolic and renal disease therapeutics.

Application

• Primary Active Pharmaceutical Ingredient (API) in urate-lowering drugs.
• Research and development of novel treatments for hyperuricemia.
• Formulation of prescription medications for chronic gout management.
• Preclinical and clinical studies investigating xanthine oxidase inhibition.
• Reference standard for analytical and quality control laboratories.

Basic Information

Product Name	Topiroxostat
CAS No.	577778-58-6
Molecular Formula	C₁₃H₉N₅O₂
Molecular Weight	267.25 g/mol
Synonyms	Topiroxostat; UR-1102; 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid; 2-[3-Cyano-4-isobutoxyphenyl]-4-methyl-1,3-thiazole-5-carboxylic acid; 5-Carboxy-4-methyl-2-[3-cyano-4-(2-methylpropoxy)phenyl]thiazole; UR 1102; UR1102; Feburic (Trade Name)
EINECS	Contact for details

Quality Control

Our Topiroxostat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity pharmaceutical standards, including identity, assay, and impurity profile verification. Certificates of Analysis (COA) confirming compliance with relevant specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.