Description

42-(Dimethylphosphinate)Rapamycin is a chemically modified derivative of the potent immunosuppressant and mTOR inhibitor, rapamycin. This specific analog is designed to enhance stability, solubility, or alter the pharmacological profile for advanced research and development applications. It is primarily utilized by pharmaceutical researchers and biotech companies engaged in the development of novel therapeutics targeting cancer, autoimmune diseases, and organ transplantation. The compound offers a critical tool for probing mTOR pathway biology and developing next-generation targeted therapies.

Application

• Biomedical Research: A key reagent for studying mTOR (mammalian target of rapamycin) signaling pathways, cellular growth, proliferation, and autophagy.
• Drug Discovery & Development: Serves as a lead compound or intermediate in the synthesis of novel rapamycin analogs with improved pharmacokinetic properties.
• Oncology Research: Investigated for its potential anti-cancer properties and utility in combination therapies targeting tumor metabolism and growth.
• Immunology Studies: Used in research focused on T-cell activation, immunosuppression, and the treatment of autoimmune disorders.
• Chemical Biology: Employed as a molecular probe to identify and validate new biological targets and mechanisms of action.
• Preclinical Studies: Utilized in animal models to evaluate the efficacy and toxicity profiles of new therapeutic candidates.

Basic Information

Product Name	42-(Dimethylphosphinate)Rapamycin
CAS No.	572924-54-0
Molecular Formula	C56H87NO14P
Molecular Weight	1028.25 g/mol
Synonyms	Rapamycin 42-(Dimethylphosphinate); 42-Dimethylphosphinate Rapamycin; 42-(Dimethylphosphinate)-Rapamycin; Dimethylphosphinate Rapamycin Derivative; mTOR Inhibitor Derivative; Sirolimus Derivative; AY-22989 (related analog); RAD001 (Everolimus) related compound
EINECS	Contact for details

Quality Control

Our 42-(Dimethylphosphinate)Rapamycin is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research chemicals, ensuring reliable and reproducible results for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.