Description

8-Hydroxy-2'-Deoxyguanosine (15N5, 98%) 95% Chemical Purity is a stable isotope-labeled analog of a critical oxidative DNA lesion, specifically designed for advanced analytical research. This compound is essential for the accurate quantification and mechanistic study of oxidative stress in biological systems, providing an internal standard for mass spectrometry. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors focused on genomics, biomarker discovery, and toxicology.

Application

• Internal standard for the precise quantification of 8-OHdG, a biomarker of oxidative DNA damage, via LC-MS/MS and GC-MS.
• Critical reagent in biomarker research and validation studies for conditions linked to oxidative stress, such as cancer, neurodegenerative diseases, and aging.
• Use in pharmaceutical R&D for assessing the genotoxic potential and antioxidant efficacy of new drug candidates.
• Essential component in clinical research assays to evaluate environmental or lifestyle impacts on DNA integrity.
• Application in forensic and doping control laboratories for specialized analytical protocols requiring high-purity isotope-labeled standards.
• Tool for method development and validation in analytical chemistry to ensure accuracy, precision, and regulatory compliance.

Basic Information

Product Name	8-Hydroxy-2'-Deoxyguanosine (15N5, 98%) 95% Chemical Purity
CAS No.	569649-11-2
Molecular Formula	C10H14N515N5O6
Molecular Weight	Contact for details
Synonyms	8-OHdG-(15N5); 8-Hydroxy-2'-deoxyguanosine-15N5; 8-Oxo-2'-deoxyguanosine-15N5; 8-Oxo-dG-(15N5); Oxidative DNA Damage Standard (15N5); 8-Hydroxydeoxyguanosine (15N5); 7,8-Dihydro-8-oxo-2'-deoxyguanosine-15N5; Isotopically Labeled 8-OHdG
EINECS	Contact for details

Quality Control

Every batch of our 8-Hydroxy-2'-Deoxyguanosine (15N5) is manufactured and analyzed under strict quality management systems. The product is characterized to confirm the 95% chemical purity and the 98% isotopic enrichment (15N5) as stated. Our quality control includes rigorous testing via NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and identity is provided with each shipment to ensure traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storage under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Enrichment (15N5)	≥ 98.0 atom %
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.