Description

2-Di-tert-Butylphosphino-2',4',6'-Triisopropylbiphenyl is a highly specialized, sterically demanding monodentate phosphine ligand, widely recognized in the chemical industry by its common abbreviation t-BuXPhos. This compound is critically important for enabling challenging cross-coupling reactions, particularly Buchwald-Hartwig aminations, by providing exceptional catalytic activity and selectivity. It is an essential tool for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require efficient and reliable methods for constructing carbon-nitrogen and carbon-carbon bonds.

Application

• Pharmaceutical Intermediate Synthesis: A key ligand for palladium-catalyzed Buchwald-Hartwig amination, enabling the efficient production of complex amine-containing drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the synthesis of novel herbicides, fungicides, and insecticides that require the formation of aryl amine bonds under mild conditions.
• Advanced Material Development: Facilitates cross-coupling reactions in the creation of organic light-emitting diodes (OLEDs), conductive polymers, and liquid crystals.
• Catalyst Preparation: Employed in the preparation of pre-formed, highly active palladium complexes and catalysts for specialized synthetic applications.
• Academic & Industrial R&D: A staple reagent in research laboratories for method development and exploring new synthetic pathways in organic and medicinal chemistry.
• Fine Chemical Production: Applied in the scalable synthesis of specialty chemicals, dyes, and pigments where selective coupling reactions are paramount.

Basic Information

Product Name	2-Di-tert-Butylphosphino-2',4',6'-Triisopropylbiphenyl
CAS No.	564483-19-8
Molecular Formula	C31H49P
Molecular Weight	452.70 g/mol
Synonyms	t-BuXPhos; Di-tert-butyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphine; 2-(Di-tert-butylphosphino)-2',4',6'-triisopropylbiphenyl; 2-(Di-tert-butylphosphino)-2',4',6'-triisopropyl-1,1'-biphenyl; tBuXPhos ligand; XPhos-type ligand (t-Bu variant); DTBP-TIPB; 2-Biphenylyldi-tert-butylphosphine, 2',4',6'-triisopropyl-
EINECS	Contact for details

Quality Control

Our 2-Di-tert-Butylphosphino-2',4',6'-Triisopropylbiphenyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 13C, 31P) and HPLC analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
31P NMR Purity	≥ 98.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.