Description

X-Phos is a specialized, monodentate phosphine ligand widely recognized for its exceptional performance in palladium-catalyzed cross-coupling reactions. Its primary value lies in enabling highly efficient and selective transformations, crucial for constructing complex molecular architectures in demanding synthetic workflows. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-performance catalysts for scale-up and production.

Application

• As a key ligand in Buchwald-Hartwig amination reactions for C-N bond formation.
• Catalyst component in Suzuki-Miyaura cross-coupling for biaryl synthesis.
• Facilitates Negishi and Kumada couplings for C-C bond construction.
• Used in α-arylation of carbonyl compounds and related transformations.
• Enables efficient amination of aryl halides and sulfonates.
• Applied in the synthesis of pharmaceutical intermediates and active ingredients.
• Research tool in methodology development for new catalytic processes.
• Component in pre-formed catalyst kits and specialty reagent formulations.

Basic Information

Item	Detail
Product Name	X-Phos
CAS No.	564483-18-7
Molecular Formula	C26H31OP
Molecular Weight	390.50 g/mol
Synonyms	2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl; Di(1-adamantyl)-n-butylphosphine (common mis-association); XPhos; DavePhos (related ligand class); Biarylphosphine ligand; Buchwald ligand; Pd-tetrakis alternative; Cross-coupling catalyst ligand
EINECS	Contact for details

Quality Control

Our X-Phos is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic activity. Each lot undergoes comprehensive analysis, including HPLC for purity and NMR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key parameters relevant to its performance as a ligand. Our quality system supports compliance with cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C for long-term stability. This material is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.