Description

(+)-1,2-Bis[(2S,5S)-2,5-Dimethyl-(3S,4S)-3,4-Dihydroxyphospholano]Benzene Bis(Trifluoromethanesulfonate)Salt is a high-value, enantiomerically pure organophosphorus ligand precursor, specifically designed for the creation of highly selective asymmetric catalysts. Its core value lies in enabling the synthesis of chiral transition metal complexes that drive efficient and stereoselective chemical transformations critical to modern fine chemical and pharmaceutical manufacturing. This advanced chiral auxiliary is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise control over stereochemistry in hydrogenation, hydroformylation, and other key catalytic processes.

Application

• Asymmetric Hydrogenation Catalysis: Serves as a privileged ligand precursor for rhodium, ruthenium, and iridium complexes used in the enantioselective reduction of prochiral olefins, ketones, and imines.
• Pharmaceutical Intermediate Synthesis: Critical for the production of chiral active pharmaceutical ingredients (APIs), including β-amino acids, unnatural amino acids, and other complex molecular architectures.
• Agrochemical Product Development: Employed in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators to enhance efficacy and reduce environmental impact.
• Fine Chemical and Flavor/Fragrance Manufacturing: Enables the asymmetric synthesis of high-value chiral intermediates for flavors, fragrances, and advanced materials.
• Academic and Industrial R&D: A key reagent for methodological development in organic synthesis and catalysis research within university and corporate laboratories.
• Process Chemistry Optimization: Used to develop scalable, efficient, and cost-effective catalytic routes for the commercial production of single-enantiomer compounds.

Basic Information

Item	Details
Product Name	(+)-1,2-Bis[(2S,5S)-2,5-Dimethyl-(3S,4S)-3,4-Dihydroxyphospholano]Benzene Bis(Trifluoromethanesulfonate)Salt
CAS No.	552829-96-6
Molecular Formula	C24H32F6O12P2S2
Molecular Weight	764.57 g/mol
Synonyms	(S,S)-Me-DuPhos Triflate Salt; (2S,5S)-1,1'-(-1,2-Phenylene)bis[2,5-dimethylphospholane] bis(trifluoromethanesulfonate); (S,S)-Me-DuPhos Bis(triflate); (+)-1,2-Bis((2S,5S)-2,5-dimethylphospholano)benzene bis(trifluoromethanesulfonate); DuPhos ligand precursor; (S,S)-Me-DuPhos·2HOTf; (S,S)-1,2-Bis(2,5-dimethylphospholano)benzene bis(trifluoromethanesulfonate)
EINECS	Contact for details

Quality Control

Our production of this high-purity chiral ligand adheres to stringent quality protocols to ensure batch-to-batch consistency and optimal performance in sensitive catalytic applications. Each lot is characterized using advanced analytical techniques, including Chiral HPLC, 1H/31P NMR spectroscopy, and elemental analysis, to confirm enantiomeric excess, chemical purity, and identity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For long-term stability, store at 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.