Description

Capadenoson is a highly selective and potent partial agonist of the adenosine A1 receptor, representing a significant compound in cardiovascular and metabolic research. Its mechanism of action makes it a valuable pharmacological tool for investigating heart rate regulation, cardiac protection, and energy metabolism pathways. This compound is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on developing novel therapeutic agents for conditions such as atrial fibrillation, heart failure, and type 2 diabetes.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the discovery and preclinical development of cardioprotective and anti-arrhythmic drugs.
• Mechanistic Studies: Used extensively in in vitro and in vivo studies to elucidate the role of adenosine A1 receptor signaling in cardiac function, ischemia-reperfusion injury, and metabolic syndrome.
• Biochemical Assay Development: Employed as a critical ligand in high-throughput screening (HTS) campaigns and binding assays to identify and characterize new adenosine receptor modulators.
• Academic Research: Supports fundamental pharmacological and physiological research in university and institutional labs exploring cardiovascular and neurological systems.
• Safety & Toxicology Profiling: Utilized in preclinical safety pharmacology studies to assess the therapeutic window and potential side effects of A1 receptor-targeted compounds.

Basic Information

Item	Details
Product Name	Capadenoson
CAS No.	544417-40-5
Molecular Formula	C₂₀H₂₅N₅O₃
Molecular Weight	383.45 g/mol
Synonyms	2-Amino-N-[(1S,2R,3S,4R,5S)-4-[6-Amino-2-(1-methylpyrazol-4-yl)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]acetamide; BAY 68-4986; Capadenoson (BAY 68-4986); GR 79236 (related analog); Adenosine A1 Receptor Partial Agonist
EINECS	Contact for details

Quality Control

Our Capadenoson is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for research chemicals, with specifications designed to meet the rigorous demands of pharmaceutical R&D. Certificates of Analysis are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, ideally between 15-25°C, in a dry environment. For long-term storage, consider keeping the material under inert atmosphere to ensure stability. Keep the container in a well-ventilated place and away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.