Description

(2S)-1-[(4S)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]-2-(Diphenylphosphino)-Ferrocene is a highly specialized chiral ferrocenyl phosphine-oxazoline ligand, a critical component in asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, which are essential for the efficient and cost-effective synthesis of single-enantiomer pharmaceutical intermediates and fine chemicals. This product is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control in their synthetic processes.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones to produce chiral building blocks.
• Pharmaceutical Intermediate Synthesis: Used in the catalytic preparation of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Production: Facilitates the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Asymmetric C-C Bond Formation: Employed in reactions such as allylic alkylation and conjugate addition for constructing complex chiral molecules.
• Academic & Process Chemistry Research: A valuable tool for developing new catalytic methodologies and optimizing synthetic routes in R&D laboratories.
• Fine Chemical Manufacturing: Enables the production of high-value chiral flavors, fragrances, and specialty materials.

Basic Information

Product Name	(2S)-1-[(4S)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]-2-(Diphenylphosphino)-Ferrocene
CAS No.	541540-58-3
Molecular Formula	C36H32FeNOP
Molecular Weight	581.47 g/mol
Synonyms	(S,S)-FerroPHOX; (S,S)-2-[2-(Diphenylphosphino)ferrocenyl]-4-benzyl-4,5-dihydrooxazole; (S,S)-4-Benzyl-2-[2-(diphenylphosphino)ferrocenyl]-2-oxazoline; (S,S)-2-[2-(Diphenylphosphino)ferrocenyl]-4-benzyl-4,5-dihydrooxazole; Josiphos-type ligand derivative; Chiral Ferrocenyl Phosphine-Oxazoline Ligand; (S,S)-Fe-Phox; PFBO
EINECS	Contact for details

Quality Control

Our (2S)-1-[(4S)-4,5-Dihydro-4-(Phenylmethyl)-2-Oxazolyl]-2-(Diphenylphosphino)-Ferrocene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis, to ensure it meets the high standards required for catalytic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.