Description

C17 Globotriaosylceramide (D18:1/17:0) is a high-purity, well-defined glycosphingolipid standard, critical for research and analytical applications. This compound is essential for scientists requiring precise molecular tools to study lipid metabolism, cellular signaling, and biomarker discovery. It is primarily utilized by researchers in academic institutions, pharmaceutical R&D, and diagnostic laboratories focusing on lysosomal storage disorders, glycolipid biology, and mass spectrometry-based lipidomics.

Application

• Biomarker Research & Standard: Serves as a critical reference standard in the study of Fabry disease and other sphingolipidoses for accurate quantification of globotriaosylceramide (Gb3) species.
• Mass Spectrometry & Lipidomics: Used as a high-purity internal standard or calibrant in LC-MS/MS and MALDI-TOF workflows for precise lipid profiling and quantification.
• Enzyme Activity Assays: Employed as a specific substrate for in vitro assays to measure the activity of enzymes like α-galactosidase A.
• Cell Biology Studies: Utilized in research investigating the role of specific Gb3 isoforms in cell membrane structure, signal transduction, and pathogen binding.
• Diagnostic Kit Development: Acts as a key raw material in the development and calibration of diagnostic kits and reagents for genetic and metabolic disorders.
• Pharmaceutical R&D: Supports drug discovery programs targeting glycolipid-mediated diseases, including the evaluation of enzyme replacement therapies and pharmacological chaperones.

Basic Information

Product Name	C17 Globotriaosylceramide (D18:1/17:0)
CAS No.	536745-81-0
Molecular Formula	C59H111NO13
Molecular Weight	1018.52 g/mol
Synonyms	Gb3 (d18:1/17:0); Globotriaosylceramide (d18:1/17:0); C17-Gb3; CD77; Galα1-4Galβ1-4Glcβ1-Cer (d18:1/17:0); Globotriaosylsphingosine (D18:1/17:0); Pk antigen; Ceramide Trihexoside (D18:1/17:0)
EINECS	Contact for details

Quality Control

Our C17 Globotriaosylceramide is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 standards, and our quality protocols are designed to meet the rigorous demands of analytical and pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is easily oxidized; containers should be sealed under an inert atmosphere (e.g., argon or nitrogen) after each use to maintain purity and prevent degradation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform/methanol mixtures, DMSO
Loss on Drying	≤ 2.0 %
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.