Description

Methyl 2,2-Difluoro-2H-1,3-Benzodioxole-4-Carboxylate is a high-value fluorinated heterocyclic building block, specifically a difluorobenzodioxole derivative, prized for its unique electronic and steric properties. This compound is essential for introducing the difluoromethylenedioxy (O-CF2-O) pharmacophore into target molecules, a key modification in modern medicinal chemistry. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, where its incorporation can significantly influence metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A critical synthon for developing new drug candidates, particularly in oncology, CNS disorders, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science Research: Serves as a precursor for specialty polymers and advanced organic electronic materials requiring fluorinated aromatic units.
• Chemical Biology Probes: Employed in the design of molecular probes and inhibitors to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A key starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences industry.

Basic Information

Product Name	Methyl 2,2-Difluoro-2H-1,3-Benzodioxole-4-Carboxylate
CAS No.	531508-32-4
Molecular Formula	C9H6F2O4
Molecular Weight	216.14 g/mol
Synonyms	4-(Methoxycarbonyl)-2,2-difluoro-2H-1,3-benzodioxole; Methyl 2,2-difluorobenzo[d][1,3]dioxole-4-carboxylate; 2,2-Difluoro-2H-1,3-benzodioxole-4-carboxylic acid methyl ester; Difluorobenzodioxole methyl carboxylate; 531508-32-4; Methyl 2,2-difluoro-1,3-benzodioxole-4-carboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 2,2-Difluoro-2H-1,3-Benzodioxole-4-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials are characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.