Description

(S)-Binapine CAS NO 528854-26-4 is a high-purity, enantiomerically pure chiral ligand belonging to the binaphthyl phosphine family. It is a critical component in asymmetric catalysis, enabling the synthesis of complex chiral molecules with high enantioselectivity. This product is essential for research and development in the pharmaceutical, agrochemical, and fine chemical industries, where precise stereochemical control is paramount for creating active and effective compounds.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediates.
• Catalyst component in asymmetric cross-coupling reactions (e.g., Suzuki-Miyaura, Heck).
• Key reagent for the synthesis of enantiomerically pure natural products and active pharmaceutical ingredients (APIs).
• Use in asymmetric allylic substitution and hydroformylation reactions.
• Research and development of novel catalytic systems in academic and industrial laboratories.
• Production of chiral agrochemicals and specialty fine chemicals.

Basic Information

Product Name	(S)-Binapine
CAS No.	528854-26-4
Molecular Formula	C44H32P2
Molecular Weight	622.67 g/mol
Synonyms	(S)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl; (S)-BINAP; (S)-(-)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl; (S)-(-)-BINAP; (S)-1,1'-Binaphthalene-2,2'-diylbis(diphenylphosphine); (S)-2,2'-Bis(diphenylphosphanyl)-1,1'-binaphthyl; (11bS)-1,1'-Binaphthalene-2,2'-diylbis[diphenylphosphine]; RuPhos 203
EINECS	Contact for details

Quality Control

Our (S)-Binapine is manufactured under strict quality control protocols to ensure high enantiomeric excess (ee) and chemical purity, meeting the stringent requirements for catalytic applications. Each batch is analyzed using advanced techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and enantiomeric excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is easily oxidized and light-sensitive.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Melting Point	241 - 245 °C
Specific Rotation	-209° to -215° (c=1 in THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.