Description

n-Carbobenzoxyglycine-13C2,15N is a stable isotope-labeled derivative of the protected amino acid, Cbz-Glycine, specifically enriched with carbon-13 and nitrogen-15. This compound is essential for advanced research and development in quantitative proteomics, metabolic pathway tracing, and pharmacokinetic studies, where precise mass spectrometry detection is required. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and contract research organizations (CROs) specializing in isotope dilution mass spectrometry and biomarker discovery.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative internal standard in liquid chromatography-tandem mass spectrometry for the accurate measurement of glycine or related peptide metabolites in complex biological matrices.
• Metabolic Flux Analysis: Used as a tracer to study glycine metabolism, one-carbon unit transfer, and glutathione synthesis pathways in cell cultures, tissues, or whole organisms.
• Peptide Synthesis & Labeling: Acts as a building block for the solid-phase or solution-phase synthesis of isotopically labeled peptides, enabling precise protein quantification and interaction studies.
• Proteomics Research: Facilitates the development of targeted and discovery proteomics methods, improving the accuracy of protein identification and quantification.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed in the synthesis of isotopically labeled drug candidates or metabolites for definitive ADME (Absorption, Distribution, Metabolism, and Excretion) studies.
• Biomarker Validation: Provides a definitive reference standard for the validation of glycine-related biomarkers in clinical or preclinical research.

Basic Information

Product Name	n-Carbobenzoxyglycine-13C2,15N
CAS No.	525587-92-2
Molecular Formula	C1013C2H1115N1O4
Molecular Weight	Contact for details
Synonyms	N-Carbobenzoxyglycine-13C2,15N; Cbz-Glycine-13C2,15N; N-(Benzyloxycarbonyl)glycine-13C2,15N; Z-Gly-OH-13C2,15N; Benzyloxycarbonylglycine-13C2,15N; N-Cbz-glycine-13C2,15N; (13C2,15N)-N-Carbobenzyloxyglycine; Glycine, N-[(phenylmethoxy)carbonyl]-, (13C2,15N)-
EINECS	Contact for details

Quality Control

Our n-Carbobenzoxyglycine-13C2,15N is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity, critical for sensitive mass spectrometry applications. Each batch is analyzed via NMR, HPLC, and LC-MS to confirm isotopic enrichment, chemical identity, and purity. A comprehensive Certificate of Analysis (COA) detailing isotopic purity (atom % 13C and 15N), chemical purity, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (13C)	≥ 99 atom %
Isotopic Purity (15N)	≥ 98 atom %
Chemical Purity (by 1H NMR)	≥ 97%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.