Description

14,15-Ee-8(Z)-E is a high-purity, specialized epoxide derivative of arachidonic acid, a key intermediate in the biosynthesis of bioactive eicosanoids. This compound is critical for researchers and manufacturers requiring precise control over eicosanoid metabolic pathways. It is primarily utilized in advanced pharmaceutical research, biochemical studies, and as a reference standard in analytical laboratories.

Application

• Biochemical Research: A vital intermediate for studying the cytochrome P450 (CYP) epoxygenase pathway and the biosynthesis of Epoxyeicosatrienoic Acids (EETs).
• Pharmaceutical Development: Serves as a key building block or reference compound in the development of novel therapeutics targeting cardiovascular, renal, and inflammatory diseases.
• Analytical Reference Standard: Used for the calibration of analytical equipment (HPLC, LC-MS) and for the qualitative and quantitative analysis of eicosanoid metabolites in biological samples.
• Cell Signaling Studies: Employed in vitro and in vivo to investigate the role of specific EET regioisomers in cellular signaling, angiogenesis, and vascular function.
• Metabolite Synthesis: Acts as a precursor for the synthesis of downstream metabolites and analogs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	14,15-Ee-8(Z)-E
CAS No.	519038-93-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	14,15-EET 8(Z)-E; 14,15-Epoxy-8Z-eicosatrienoic Acid; 14(15)-Epoxy-8Z-eicosa-5Z,8Z,11Z-trienoic Acid; 14,15-Epoxy-5Z,8Z,11Z-eicosatrienoic Acid (8Z isomer); 14,15-EET (8Z-E); Arachidonic acid, 14,15-epoxy-8Z-isomer; 14,15-Epoxy-8-cis-eicosatrienoic Acid
EINECS	Contact for details

Quality Control

Every batch of 14,15-Ee-8(Z)-E is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity (by HPLC), identity confirmation (by NMR/MS), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical: 97-99%)
Solubility	Soluble in ethanol, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.