Description

Cyclosporin A, 6-[(2S,3R,4R,6E)-3-(Acetyloxy)-4-Methyl-2-(Methylamino)-6,8-Nonadienoic Acid]- is a high-purity, chemically defined derivative of the well-known immunosuppressive agent Cyclosporin A, offering a precise molecular structure for advanced research and development. This compound is critical for scientists exploring structure-activity relationships (SAR) and developing novel therapeutic agents or biochemical probes. It is primarily targeted at pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in immunology, medicinal chemistry, and process development.

Application

• Medicinal Chemistry Research: A key intermediate for synthesizing novel Cyclosporin A analogs to study immunosuppressive mechanisms and improve therapeutic profiles.
• Biochemical Probe Development: Used to create labeled or modified probes for investigating cyclophilin binding and intracellular signaling pathways.
• Process Chemistry & Scale-Up: Serves as a critical reference standard and building block in the development and validation of synthetic routes for active pharmaceutical ingredients (APIs).
• Academic Research: Employed in university and institutional labs for fundamental studies in immunology, enzymology, and molecular biology.
• Quality Control & Analytical Standards: Functions as a certified reference material (CRM) for HPLC, LC-MS, and NMR analysis in pharmaceutical quality assurance.

Basic Information

Product Name	Cyclosporin A, 6-[(2S,3R,4R,6E)-3-(Acetyloxy)-4-Methyl-2-(Methylamino)-6,8-Nonadienoic Acid]-
CAS No.	515814-02-5
Molecular Formula	C62H111N11O12
Molecular Weight	1202.6 g/mol
Synonyms	6-[(2S,3R,4R,6E)-3-(Acetyloxy)-4-Methyl-2-(Methylamino)-6,8-Nonadienoic Acid]-Cyclosporin A; Cyclosporin A Derivative; Cyclosporin A, 6-[(2S,3R,4R,6E)-3-(Acetyloxy)-4-Methyl-2-(Methylamino)-6,8-Nonadienoic Acid]; CsA Derivative; Modified Cyclosporin A; Immunosuppressant Intermediate; Cyclophilin Ligand Analog
EINECS	Contact for details

Quality Control

Our Cyclosporin A derivative is produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC purity analysis, NMR structural confirmation, and mass spectrometry, to ensure identity, potency, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to reach room temperature before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.