Description

(S)-n-Methyl-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethylamine is a high-value chiral amine building block featuring a trifluoromethylated aromatic core. This compound matters for its role as a key intermediate in the synthesis of advanced pharmaceutical agents, particularly in the development of receptor antagonists and enzyme inhibitors. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry and process development for new drug candidates.

Application

• As a chiral intermediate in the synthesis of active pharmaceutical ingredients (APIs).
• In medicinal chemistry research for structure-activity relationship (SAR) studies.
• For the development of NK1 receptor antagonists and related neurokinin inhibitors.
• As a building block for ligands in asymmetric catalysis.
• In the preparation of diagnostic compounds and imaging agents.
• For process chemistry and route scouting in pharmaceutical manufacturing.

Basic Information

Product Name	(S)-n-Methyl-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethylamine
CAS No.	511256-36-3
Molecular Formula	C11H11F6N
Molecular Weight	271.20 g/mol
Synonyms	(S)-1-[3,5-Bis(trifluoromethyl)phenyl]-N-methylethanamine; (S)-N-Methyl-1-[3,5-bis(trifluoromethyl)phenyl]ethanamine; (S)-α-Methyl-3,5-bis(trifluoromethyl)benzeneethanamine, N-methyl-; (S)-N-Methyl-1-(3,5-bis(trifluoromethyl)phenyl)ethylamine; (S)-1-(3,5-Bis(trifluoromethyl)phenyl)-N-methylethylamine; (S)-N-Methyl-3,5-bis(trifluoromethyl)phenethylamine; Aprepitant Intermediate
EINECS	Contact for details

Quality Control

Our (S)-n-Methyl-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethylamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.