Description

4-Iodo-2,3-Difluorobenzoic Acid is a high-purity, multi-functional halogenated benzoic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of iodine and fluorine atoms on the aromatic ring, enabling precise cross-coupling reactions and the introduction of fluorinated motifs. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for developing new-generation herbicides and fungicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Used in the creation of specialty polymers and liquid crystals, where the halogenated benzoic acid core modifies material properties.
• Cross-Coupling Reactions: The iodine atom serves as an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to construct complex biaryl structures.
• Fluorination Chemistry Studies: Valuable substrate for investigating nucleophilic aromatic substitution (SNAr) and other fluorination-related mechanistic pathways.
• Ligand and Catalyst Development: Starting material for synthesizing novel chelating ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	4-Iodo-2,3-Difluorobenzoic Acid
CAS No.	501433-05-2
Molecular Formula	C7H3F2IO2
Molecular Weight	283.99 g/mol
Synonyms	2,3-Difluoro-4-iodobenzoic Acid; Benzoic acid, 4-iodo-2,3-difluoro-; 4-Iodo-2,3-difluorobenzoic acid; 501433-05-2; 2,3-Difluoro-4-iodobenzoic acid; 4-Iodo-2,3-difluoro-benzoic acid; AKOS005258156; FT-0773668; SCHEMBL21808927; A839248; 4-Iodo-2,3-difluoro-benzoicacid
EINECS	Contact for details

Quality Control

Our 4-Iodo-2,3-Difluorobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure compliance with exacting R&D and production standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Assay	≥95.0% (by titration)
Melting Point	Contact for details
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.