Description

2-(2,4-Difluorophenyl)-Isonicotinic Acid is a high-purity, multi-functional heterocyclic building block featuring a difluorophenyl substituent. This compound is valued for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its unique fluorinated structure imparts desirable biological activity and metabolic stability. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and anti-infective drug candidates.
• Agrochemical Synthesis: Used as a building block for creating advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of fluorine atoms.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials due to its aromatic and heterocyclic core.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biochemical research and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated intermediates.

Basic Information

Product Name	2-(2,4-Difluorophenyl)-Isonicotinic Acid
CAS No.	500586-44-7
Molecular Formula	C12H7F2NO2
Molecular Weight	235.19 g/mol
Synonyms	2-(2,4-Difluorophenyl)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 2-(2,4-difluorophenyl)-; Isonicotinic acid, 2-(2,4-difluorophenyl)-; 2-(2,4-Difluorophenyl)isonicotinic acid; 500586-44-7; 2-(2,4-Difluorophenyl)-4-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 2-(2,4-Difluorophenyl)-Isonicotinic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes comprehensive analysis via HPLC, NMR, and MS to meet the stringent requirements of research and industrial synthesis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to guarantee traceability and compliance with your project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.