Description

L-Valine, n-[1-[2-(Diphenylphosphino)Phenyl]-2-Oxo-2-[(2,4,6-Trimethylphenyl)Amino]Ethyl]-, Methyl Ester (9Ci) is a sophisticated chiral organophosphorus compound that serves as a high-value building block and ligand in advanced chemical synthesis. Its molecular architecture, combining a valine-derived backbone with a diphenylphosphino group and a sterically hindered aniline, makes it a critical component for developing asymmetric catalysts and pharmaceutical intermediates. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical sectors who require precise stereochemical control and novel ligand frameworks for transition metal catalysis.

Application

• Asymmetric Catalysis: As a chiral phosphine ligand for transition metal-catalyzed reactions, including hydrogenation, cross-coupling, and hydroformylation.
• Pharmaceutical Intermediate: Key building block in the synthesis of complex, optically active active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and development of chiral pesticides and herbicides requiring specific stereochemistry for efficacy.
• Material Science Research: A precursor for creating novel chiral organometallic complexes and functional materials.
• Academic & Industrial R&D: A valuable tool for method development in organic synthesis and catalysis studies.

Basic Information

Product Name	L-Valine, n-[1-[2-(Diphenylphosphino)Phenyl]-2-Oxo-2-[(2,4,6-Trimethylphenyl)Amino]Ethyl]-, Methyl Ester (9Ci)
CAS No.	500316-83-6
Molecular Formula	C33H35N2O3P
Molecular Weight	538.62 g/mol
Synonyms	Methyl (2S)-2-[[1-[2-(diphenylphosphanyl)phenyl]-2-oxo-2-[(2,4,6-trimethylphenyl)amino]ethyl]amino]-3-methylbutanoate; L-Valine, N-[1-[2-(diphenylphosphino)phenyl]-2-oxo-2-[(2,4,6-trimethylphenyl)amino]ethyl]-, methyl ester; Chiral Valine-Derived Phosphine Ligand; (S)-Methyl 2-((1-(2-(diphenylphosphino)phenyl)-2-oxo-2-(mesitylamino)ethyl)amino)-3-methylbutanoate
EINECS	Contact for details

Quality Control

Our production of this advanced chemical intermediate adheres to stringent quality protocols. Every batch is characterized and tested to ensure high chiral purity and chemical integrity, with specifications typically covering identity, assay, and impurity profiles via techniques like HPLC and NMR. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all relevant analytical data. We support cGMP and ISO 9001 compliant manufacturing environments for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.