Description

L-Valine, n-[2-[(1,1-Dimethylethyl)Amino]-1-[2-(Diphenylphosphino)Phenyl]-2-Oxoethyl]-, Methyl Ester (9Ci) is a sophisticated chiral organophosphorus compound that serves as a critical building block in advanced chemical synthesis. This high-value specialty chemical is engineered for applications requiring precise stereochemistry and ligand functionality. It is primarily utilized by research institutions and pharmaceutical developers engaged in the creation of novel catalysts, complex intermediates, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Catalyst Ligand Synthesis: Serves as a sophisticated precursor for constructing chiral phosphine-based ligands used in asymmetric catalysis, including hydrogenation and cross-coupling reactions.
• Chemical Research & Development: An essential tool for medicinal chemists and process chemists in exploring new synthetic pathways and optimizing reaction conditions.
• Advanced Material Science: Used in the development of specialized polymers and materials where specific molecular architecture is required.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in pharmaceutical and chemical analysis.

Basic Information

Product Name	L-Valine, n-[2-[(1,1-Dimethylethyl)Amino]-1-[2-(Diphenylphosphino)Phenyl]-2-Oxoethyl]-, Methyl Ester (9Ci)
CAS No.	500316-80-3
Molecular Formula	C30H37N2O3P
Molecular Weight	504.60 g/mol
Synonyms	L-Valine, N-[2-[(1,1-dimethylethyl)amino]-1-[2-(diphenylphosphino)phenyl]-2-oxoethyl]-, methyl ester; Methyl (2S)-2-[[(2R)-2-[(tert-butyl)amino]-2-oxo-1-[2-(diphenylphosphanyl)phenyl]ethyl]amino]-3-methylbutanoate; tert-Butyl [(1R)-2-(diphenylphosphino)benzoyl]-L-valyl-methyl ester amide; Chiral Valine-Derived Phosphine Ester; (R)-2-((S)-2-((tert-Butylamino)-2-oxo-1-(2-(diphenylphosphino)phenyl)ethyl)amino)-3-methylbutanoic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of this high-purity specialty chemical adheres to stringent Good Manufacturing Practice (GMP) principles where applicable. Every batch is subjected to comprehensive analytical characterization, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity, and specific impurities is provided with each shipment to ensure traceability and meet the exacting requirements of pharmaceutical and advanced research applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.