Description

L-Serine-15N is a stable isotope-labeled analog of the essential amino acid L-serine, where the nitrogen atom is enriched with the 15N isotope. This product is critical for advanced research applications requiring precise metabolic tracing and structural elucidation in complex biological systems. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic companies engaged in nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and metabolic pathway analysis.

Application

• Biomedical Research Tracer: Used as a stable isotope-labeled internal standard in quantitative proteomics and metabolomics studies.
• NMR Spectroscopy: Essential for protein structure determination and dynamics studies due to the distinct magnetic properties of the 15N nucleus.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed to trace the metabolic fate of novel drug candidates in preclinical studies.
• Nutritional Science: Applied in research investigating amino acid metabolism, protein synthesis rates, and turnover in vivo.
• Diagnostic Assay Development: Serves as a key component in calibrating and validating advanced clinical mass spectrometry assays.

Basic Information

Product Name	L-Serine-15N
CAS No.	59935-32-9
Molecular Formula	C₃H₇¹⁵NO₃
Molecular Weight	106.08 g/mol (for ¹⁵N labeled)
Synonyms	(2S)-2-Amino-3-hydroxypropanoic-¹⁵N acid; L-(-)-Serine-¹⁵N; Ser-¹⁵N; (S)-Serine-¹⁵N; 15N Labeled L-Serine; L-Serine (15N); Stable Isotope L-Serine; ¹⁵N-L-Serine
EINECS	Contact for details

Quality Control

Our L-Serine-15N is produced under controlled conditions to ensure exceptional isotopic and chemical purity. Each batch is subjected to rigorous analytical testing, including NMR, HPLC, and mass spectrometry, to verify isotopic enrichment (typically ≥98 atom % ¹⁵N) and chemical purity (≥98%). Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment (NMR/MS)	≥ 98 atom % ¹⁵N
Optical Rotation	+13.5° to +15.5° (c=10 in 1N HCl)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.