Description

Isocyclosporin A is a specialized, high-purity cyclic peptide derivative of the well-known immunosuppressant Cyclosporin A. This compound is of significant interest in advanced pharmaceutical research and development, particularly for studying structure-activity relationships and metabolic pathways. It serves as a critical intermediate and reference standard for scientists in the fields of immunology, oncology, and medicinal chemistry. Global B2B clients rely on our supply for its consistent quality and application in cutting-edge therapeutic discovery.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Medicinal Chemistry Research: Serves as a key intermediate or analog in the synthesis and study of novel immunosuppressive and anti-inflammatory agents.
• Metabolic Studies: Employed in pharmacokinetic and metabolic pathway investigations to understand the biotransformation of cyclosporine derivatives.
• Biochemical Assay Development: Utilized as a tool compound in high-throughput screening (HTS) and in vitro assays targeting cyclophilin proteins.
• Academic & Institutional Research: Supports basic research in immunology and cell biology at universities and contract research organizations (CROs).
• Impurity Profiling: Acts as a specified impurity standard for the analysis and control of Cyclosporin A active pharmaceutical ingredient (API) batches.

Basic Information

Product Name	Isocyclosporin A
CAS No.	59865-16-6
Molecular Formula	C62H111N11O12
Molecular Weight	1202.6 g/mol
Synonyms	[Iso-MeBmt]1-Cyclosporin A; Cyclosporin A, 1-isomer; 1-Iso-Cyclosporin A; Iso-CsA; [Dihydro-MeBmt]1-Cyclosporin; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-[(1R,2R,6S)-1-hydroxy-2-methyl-6-(1-methylethenyl)cyclohexyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazatricyclo[30.3.0.012,16]pentatriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
EINECS	Contact for details

Quality Control

Our Isocyclosporin A is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS and NMR for structural confirmation, and stringent control of related substances. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure traceability and compliance with research-grade standards. We support cGMP documentation requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.