Description

Dihydrocyclosporin A is a chemically modified derivative of the potent immunosuppressive cyclic peptide, Cyclosporin A. This compound is of significant interest in pharmaceutical research and development, particularly for exploring structure-activity relationships and developing novel therapeutic agents. It serves as a critical intermediate and reference standard for scientists in the fields of immunology, oncology, and medicinal chemistry. The product is supplied under stringent quality control to ensure consistency for research and development applications.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel immunosuppressive or anti-inflammatory drug candidates.
• Biochemical Research: Used as a reference standard and probe in studies investigating the mechanism of action of cyclophilin inhibition and calcineurin signaling pathways.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new analogs with improved efficacy or reduced side effects.
• Quality Control & Analytical Testing: Functions as a certified reference material (CRM) for the identification and quantification of related substances in Cyclosporin A APIs and finished drug products.
• Academic Research: Utilized in university and institutional labs for fundamental research in immunology and cellular signal transduction.

Basic Information

Product Name	Dihydrocyclosporin A
CAS No.	59865-15-5
Molecular Formula	C62H111N11O12
Molecular Weight	1202.6 g/mol
Synonyms	Dihydro-Cyclosporin A; [Dihydro]Cyclosporin A; Cyclosporin H; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; UNII-9P3N7Q3T3Q; 9P3N7Q3T3Q; CsH
EINECS	Contact for details

Quality Control

Our Dihydrocyclosporin A is manufactured under a quality management system and undergoes rigorous analytical testing to ensure high purity and identity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for assay, purity, and related substances. While not intended for direct human therapeutic use, our material is produced with the consistency and traceability required for critical research and development applications. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.