Description

Cyclosporin A CAS NO 59865-13-3 is a potent, cyclic undecapeptide immunosuppressant widely recognized for its selective inhibition of T-lymphocyte activation. This compound is critical for preventing organ transplant rejection and managing autoimmune conditions, offering a targeted mechanism of action with significant therapeutic value. It is an essential active pharmaceutical ingredient (API) for pharmaceutical manufacturers, research institutions, and biotechnology companies engaged in immunology and transplant medicine.

Application

• Immunosuppressive Therapy: Primary API in oral and injectable formulations for the prevention of graft rejection in organ (kidney, liver, heart) and bone marrow transplantation.
• Autoimmune Disease Management: Used in the treatment of severe cases of psoriasis, atopic dermatitis, rheumatoid arthritis, and other T-cell mediated autoimmune disorders.
• Ophthalmic Formulations: Key component in topical eye drops (e.g., for dry eye disease) and intraocular implants to manage ocular inflammation and graft-versus-host disease.
• Pharmaceutical Research & Development: A vital reference standard and tool compound for studying calcineurin inhibition, T-cell signaling pathways, and immunology in preclinical research.
• Veterinary Medicine: Employed in canine and feline veterinary practice for managing atopic dermatitis and other immune-mediated conditions.
• Drug Delivery & Nanotechnology Research: Investigated in novel drug delivery systems, including nanoparticles and liposomes, to enhance bioavailability and reduce nephrotoxicity.

Basic Information

Product Name	Cyclosporin A
CAS No.	59865-13-3
Molecular Formula	C62H111N11O12
Molecular Weight	1202.61 g/mol
Synonyms	Cyclosporine; Ciclosporin; CsA; OL 27-400; Sandimmun; Cyclosporin; Cyclosporine A; [R-[R*,R*-(E)]]-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-α-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl)
EINECS	261-985-1

Quality Control

Our Cyclosporin A is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and related substances, to ensure compliance with pharmaceutical-grade standards. Certificates of Analysis (COA) detailing identity, potency, and impurity profiles are provided and can be tailored to meet specific pharmacopoeial requirements (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.