Description

Femoxetine CAS NO 59859-58-4 is a selective serotonin reuptake inhibitor (SSRI) compound of significant interest in pharmaceutical research and development. Its primary value lies in its potential application as a key intermediate or active pharmaceutical ingredient (API) for the synthesis of novel therapeutic agents targeting central nervous system disorders. This compound is essential for pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the development of psychotropic medications.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of advanced SSRIs and related neuropsychiatric drugs.
• Active Pharmaceutical Ingredient (API) Research: Used as a reference standard or starting material in the research and development of new antidepressant and anxiolytic drug candidates.
• Biochemical Research: Employed in in vitro studies to investigate serotonin transporter (SERT) inhibition mechanisms and structure-activity relationships (SAR).
• Preclinical Development: Utilized in the formulation of dosage forms for pharmacokinetic, pharmacodynamic, and toxicology studies during drug discovery phases.
• Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials and non-commercial batches.
• Reference Standard: Provides a high-purity compound for analytical method development, validation, and quality control testing in regulatory submissions.

Basic Information

Product Name	Femoxetine
CAS No.	59859-58-4
Molecular Formula	C20H23NO2
Molecular Weight	309.41 g/mol
Synonyms	Femoxetine; (3S)-3-(Methylamino)-1-phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-ol; FG-4963; Lilly-110140; (S)-Femoxetine; (+)-Femoxetine; 1-Phenyl-3-[[4-(trifluoromethyl)phenoxy]methyl]-3-(methylamino)-1-propanol
EINECS	Contact for details

Quality Control

Our Femoxetine is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability. Each lot undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to meet stringent specifications. We provide full traceability and support regulatory requirements with comprehensive documentation. Certificates of Analysis (COA) detailing all test results are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Optical Rotation	Specific range provided on COA
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.