Description

Acetylsalicylic Acid, [Carboxyl-14C] CAS NO 59096-14-9 is a carbon-14 radiolabeled derivative of acetylsalicylic acid (aspirin), where the radioactive isotope is specifically incorporated at the carboxyl group. This compound is an essential tool for conducting advanced metabolic, pharmacokinetic, and environmental fate studies, enabling precise tracking of the molecule in complex biological systems. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug development and biochemical research.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Tracing the absorption, distribution, metabolism, and excretion (ADME) pathways of aspirin and related salicylate compounds.
• Mechanistic Biochemical Research: Investigating the specific enzymatic targets and biochemical interactions of acetylsalicylic acid, including its cyclooxygenase (COX) inhibition.
• Environmental Fate and Ecotoxicity Studies: Monitoring the degradation, persistence, and transformation of aspirin in environmental matrices.
• Analytical Method Development: Serving as an internal standard or tracer in developing sensitive LC-MS/MS, HPLC, or scintillation counting methods for salicylates.
• Preclinical Safety and Toxicology Assessments: Used in radiolabeled mass balance studies to meet regulatory requirements for new drug applications.

Basic Information

Product Name	Acetylsalicylic Acid, [Carboxyl-14C]
CAS No.	59096-14-9
Molecular Formula	C9H8O4 (*14C at carboxyl carbon)
Molecular Weight	~180.16 g/mol (exact mass depends on 14C enrichment)
Synonyms	[Carboxyl-14C]-Aspirin; 2-(Acetyloxy)-[carboxy-14C]benzoic Acid; Acetylsalicylic Acid-14C (carboxyl labeled); [14C]ASA; Aspirin-[14C]; Radiolabeled Aspirin; 2-Acetoxy[14C]benzoic Acid; Benzoic acid, 2-(acetyloxy)-[carboxy-14C]-
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled Acetylsalicylic Acid is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to ensure radiochemical purity, chemical purity, and specific activity meet the exacting standards required for research. Certificates of Analysis (COA) detailing HPLC analysis, radiochemical purity assessment, and specific activity are supplied with each shipment. Our quality commitment supports compliance with GLP and other research guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures of 2-8°C or as specified on the label. This product is light-sensitive (store away from light). For long-term storage, consider conditions recommended for radiolabeled compounds to maintain stability and specific activity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for specific value)
Solubility	Soluble in ethanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.