Description

(-)-o-Acetyl-L-Malic Anhydride is a high-purity, chiral anhydride derivative of L-malic acid, serving as a critical chiral building block and protecting group reagent in sophisticated organic synthesis. Its value lies in enabling the stereoselective construction of complex molecules, ensuring high enantiomeric purity in the final products. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced material sectors who require reliable, high-quality intermediates for asymmetric synthesis and API development.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in oncology and antiviral drug candidates.
• Asymmetric Synthesis: Employed as a chiral auxiliary or derivatizing agent to induce stereoselectivity in carbon-carbon and carbon-heteroatom bond-forming reactions.
• Peptide Chemistry: Used for the selective protection of carboxylic acid groups in complex peptide synthesis, leveraging its chiral nature.
• Agrochemical Research: Intermediate in the development of chiral herbicides, fungicides, and plant growth regulators where specific stereochemistry is crucial for activity.
• Fine Chemical Production: Building block for manufacturing specialty chemicals, flavors, and fragrances requiring defined stereochemistry.
• Academic & R&D: Valuable reagent in university and corporate research laboratories for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(-)-o-Acetyl-L-Malic Anhydride
CAS No.	59025-03-5
Molecular Formula	C7H8O5
Molecular Weight	172.13 g/mol
Synonyms	(-)-O-Acetyl-L-malic Anhydride; (S)-(-)-O-Acetyllactic Acid Anhydride; L-(-)-O-Acetyllactic Acid Anhydride; (S)-2-(Acetyloxy)propanoic Anhydride; Acetyl-L-malic Anhydride; (S)-O-Acetyl-Lactic Acid Anhydride; 2-(Acetyloxy)propanoic Anhydride, (S)-; Acetyllactic Anhydride, L-(-)- form
EINECS	Contact for details

Quality Control

Our (-)-o-Acetyl-L-Malic Anhydride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot is subjected to comprehensive analytical testing, including chiral purity assessment by HPLC, to confirm identity, potency, and the absence of critical impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment, supporting compliance in cGMP-aligned applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.