Description

4-(Trifluoroacetyl)Benzoic Acid is a high-value fluorinated aromatic building block, distinguished by the presence of both a benzoic acid and a reactive trifluoroacetyl group. This unique bifunctional structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where fluorine substitution is desired for enhanced stability, lipophilicity, or metabolic resistance. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved performance and stability.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing their chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: A versatile reagent in academic and industrial R&D for constructing complex aromatic systems via reactions at either the acid or ketone functionality.
• Coordination Chemistry Ligand: The carboxylic acid group allows it to act as a ligand for metal complexes used in catalysis or material science.

Basic Information

Product Name	4-(Trifluoroacetyl)Benzoic Acid
CAS No.	58808-59-6
Molecular Formula	C9H5F3O3
Molecular Weight	218.13 g/mol
Synonyms	4-(Trifluoroacetyl)benzoic acid; α,α,α-Trifluoro-4-carboxyacetophenone; 4-Carboxy-α,α,α-trifluoroacetophenone; 4-(2,2,2-Trifluoroacetyl)benzoic acid; Benzoic acid, 4-(trifluoroacetyl)-; p-(Trifluoroacetyl)benzoic acid; 4-Trifluoroacetylbenzoic acid; TFABA
EINECS	Contact for details

Quality Control

Our 4-(Trifluoroacetyl)Benzoic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets the high standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.