Description

3'-Azido-3'-Deoxyadenosine is a chemically modified nucleoside analog, serving as a critical building block and research reagent in advanced biochemical synthesis. Its unique azido functional group enables click chemistry applications, facilitating the study and development of novel nucleic acid-based therapeutics and diagnostic probes. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors engaged in antiviral drug discovery, oligonucleotide synthesis, and molecular biology research.

Application

• Antiviral Research: Investigated as a potential chain terminator in the development of nucleoside reverse transcriptase inhibitors (NRTIs) for antiviral therapies.
• Click Chemistry Reagent: Utilized in bioorthogonal click chemistry reactions for labeling, conjugation, and bioconjugation of biomolecules due to its reactive azido group.
• Oligonucleotide Synthesis: Acts as a modified nucleoside precursor in the solid-phase synthesis of azide-functionalized oligonucleotides for diagnostic and therapeutic applications.
• Biochemical Probe Development: Serves as a key intermediate for creating probes to study enzyme mechanisms, particularly those involving DNA and RNA polymerases.
• Medicinal Chemistry: Used as a scaffold in structure-activity relationship (SAR) studies to design novel nucleoside analogs with enhanced pharmacological properties.
• Academic & Industrial R&D: A fundamental research chemical in laboratories focused on nucleic acid chemistry, chemical biology, and drug discovery pipelines.

Basic Information

Product Name	3'-Azido-3'-Deoxyadenosine
CAS No.	58699-62-0
Molecular Formula	C10H12N8O3
Molecular Weight	292.26 g/mol
Synonyms	3'-Azido-3'-deoxyadenosine; 3'-Azido-2',3'-dideoxyadenosine; 3'-N3-dA; 9-[(3-Azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)]adenine; Azidodideoxyadenosine; 3'-Azido-ddA; 3'-Azido-2',3'-ddA; 3'-Azido-3'-deoxy-Adenosine
EINECS	Contact for details

Quality Control

Our 3'-Azido-3'-Deoxyadenosine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.