Description

Theophylline, [8-14C] is a carbon-14 labeled derivative of the well-known methylxanthine bronchodilator, theophylline. This radiolabeled compound is essential for conducting advanced metabolic and pharmacokinetic studies, providing critical data on drug absorption, distribution, metabolism, and excretion (ADME). It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug development and biochemical research. The specific labeling at the 8-position of the purine ring makes it a vital tool for tracing the metabolic fate of theophylline and related xanthine derivatives.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Tracing the metabolic pathways and bioavailability of theophylline in preclinical and clinical research.
• Biochemical Research: Investigating the mechanism of action of methylxanthines as phosphodiesterase inhibitors and adenosine receptor antagonists.
• Analytical Method Development: Serving as an internal standard or reference material in the development of sensitive LC-MS/MS or radio-HPLC assays.
• Environmental Fate Studies: Researching the environmental degradation and persistence of xanthine-based compounds.
• Teaching and Reference Standard: Used in advanced educational settings to demonstrate radiolabeling techniques and ADME principles.

Basic Information

Item	Detail
Product Name	Theophylline, [8-14C]
CAS No.	58265-54-6
Molecular Formula	C7H814CN4O2
Molecular Weight	Contact for details
Synonyms	1,3-Dimethyl-7H-purine-2,6-dione, [8-14C]; 1,3-Dimethylxanthine-8-14C; 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione-8-14C; Theophylline-8-14C; [8-14C]Theophylline; Theo-8-14C; 1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purine-8-14C
EINECS	Contact for details

Quality Control

Every batch of Theophylline, [8-14C] is manufactured and analyzed under strict quality control protocols to ensure the highest standards of radiochemical purity and chemical identity. Our products undergo rigorous testing, including HPLC and radio-TLC analysis, to confirm specific activity and purity. A comprehensive Certificate of Analysis (COA), detailing all analytical results, is provided with each shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures, typically between 2-8°C or as specified on the label. The product is light-sensitive and should be stored away from light to maintain stability. Follow all local regulations for the safe storage of radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98% (Chemical Purity)
Radiochemical Purity (Radio-TLC/HPLC)	≥ 97%
Specific Activity	Contact for details (mCi/mmol)
Solubility	Soluble in dilute alkali, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.