Description

Clavulanic Acid is a potent β-lactamase inhibitor of significant pharmaceutical importance. Its primary value lies in its ability to protect β-lactam antibiotics, such as penicillins, from enzymatic degradation, thereby restoring their efficacy against resistant bacterial strains. This compound is therefore a critical component in the formulation of combination antibiotic therapies for human and veterinary medicine. Industries requiring this material include pharmaceutical manufacturers, research institutions, and fine chemical suppliers focused on active pharmaceutical ingredient (API) production.

Application

• Pharmaceutical API Synthesis: Key intermediate in the production of combination antibiotic drugs like amoxicillin/clavulanate potassium.
• Veterinary Medicine: Used in formulations to treat bacterial infections in animals.
• Research & Development: Serves as a reference standard and biochemical tool in microbiology and pharmacology research.
• Fine Chemical Intermediate: Employed in the synthesis of more complex β-lactamase inhibitor derivatives.
• Quality Control Laboratories: Used as an analytical standard for assay and impurity testing in pharmaceutical QC.

Basic Information

Product Name	Clavulanic Acid
CAS No.	58001-44-8
Molecular Formula	C8H9NO5
Molecular Weight	199.16 g/mol
Synonyms	(2R,3Z,5R)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid; Clavulanate; Clavulanic Acid Potassium Salt (common salt form); BRL 14151; MM 14151
EINECS	Contact for details

Quality Control

Our Clavulanic Acid is produced and tested under a strict quality management system. It meets high-purity standards suitable for pharmaceutical applications, with specifications aligned with common pharmacopeial requirements. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider conditions with low humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.