Description

Nisoxetine Hydrochloride CAS NO 57754-86-6 is a selective and potent inhibitor of the norepinephrine transporter (NET), primarily used as a reference standard and key intermediate in pharmaceutical research and development. Its high specificity makes it a critical tool for studying adrenergic neurotransmission and for the synthesis of novel therapeutic agents targeting depression, attention deficit disorders, and other central nervous system (CNS) conditions. This compound is essential for research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in neuropharmacology and psychotropic drug discovery.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in drug manufacturing.
• Neuropharmacology Research: A key biochemical tool for in vitro and in vivo studies of norepinephrine reuptake mechanisms.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical building block in the synthetic pathway for potential antidepressant and stimulant medications.
• Preclinical Development: Employed in animal model studies to investigate the efficacy and pharmacokinetics of NET inhibitors.
• Biochemical Assay Development: Utilized in high-throughput screening (HTS) to identify and characterize new chemical entities targeting the NET.

Basic Information

Product Name	Nisoxetine Hydrochloride
CAS No.	57754-86-6
Molecular Formula	C17H21NO2 • HCl
Molecular Weight	307.82 g/mol (as hydrochloride salt)
Synonyms	Nisoxetine HCl; LY-94,893; (R,S)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropylamine Hydrochloride; 3-((2-Methylphenoxy)methyl)-N-methyl-3-phenylpropylamine Hydrochloride; (±)-Nisoxetine Hydrochloride; Lilly-94893; LY94893; Nisoxetine (hydrochloride)
EINECS	Contact for details

Quality Control

Our Nisoxetine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.