Description

Nisoxetine CAS NO 57226-61-6 is a selective norepinephrine reuptake inhibitor (NRI) of significant interest in pharmaceutical research and development. This compound is a crucial intermediate and reference standard for the synthesis and analytical study of novel psychotropic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced norepinephrine reuptake inhibitors and related CNS-active compounds.
• Reference Standard: Used in analytical chemistry for method development, validation, and quality control (QC) of related active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in in vitro studies to investigate the pharmacology and mechanism of action of norepinephrine transporters.
• Preclinical Development: Serves as a tool compound in animal models for studying the effects of selective norepinephrine reuptake inhibition.
• Metabolite Synthesis: Used in the preparation of potential human metabolites for identification and safety testing during drug development.

Basic Information

Product Name	Nisoxetine
CAS No.	57226-61-6
Molecular Formula	C17H21NO2
Molecular Weight	271.35 g/mol
Synonyms	(±)-Nisoxetine; LY-94,863; 3-(2-Methoxyphenoxy)-N-methyl-3-phenylpropylamine; 3-Phenyl-3-(o-methoxyphenoxy)propylmethylamine; (RS)-N-Methyl-3-phenyl-3-(o-methoxyphenoxy)propylamine
EINECS	Contact for details

Quality Control

Our Nisoxetine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Quality is verified through comprehensive analytical techniques including HPLC, GC, and NMR. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.