Description

(R)-(+)-4-Chloromethyl-2,2-Dimethyl-1,3-Dioxolane is a high-value chiral building block and protected glycolaldehyde equivalent, essential for the stereoselective synthesis of complex organic molecules. Its primary value lies in introducing a functionalized chiral center, enabling the efficient production of enantiomerically pure pharmaceuticals and fine chemicals. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of enantiomerically pure drugs, particularly in antiviral, cardiovascular, and central nervous system (CNS) therapeutic areas.
• Asymmetric Synthesis: Serves as a versatile electrophile in nucleophilic substitution reactions to install chiral hydroxymethylene groups.
• Natural Product Synthesis: Used in the total synthesis of complex natural products requiring stereocontrolled introduction of oxygenated side chains.
• Agrochemical Active Ingredient Development: Building block for creating chiral herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Ligand and Catalyst Preparation: Precursor for synthesizing chiral ligands used in asymmetric catalysis, such as for hydrogenation or cross-coupling reactions.
• Polymer Chemistry: Monomer for creating specialty polymers with controlled stereochemistry and functional group handles for further modification.

Basic Information

Product Name	(R)-(+)-4-Chloromethyl-2,2-Dimethyl-1,3-Dioxolane
CAS No.	57044-24-3
Molecular Formula	C6H11ClO2
Molecular Weight	150.60 g/mol
Synonyms	(R)-(+)-4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane; (R)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane; (R)-2,2-Dimethyl-4-chloromethyl-1,3-dioxolane; (R)-Glyceraldehyde Acetonide Chloride; (R)-1-Chloro-3,3-dimethyl-2,4-dioxabicyclo[3.3.0]octane; (R)-Protected Chloromethyl Glycolaldehyde; (R)-Chloromethyl Acetonide; (R)-CMA
EINECS	Contact for details

Quality Control

Our (R)-(+)-4-Chloromethyl-2,2-Dimethyl-1,3-Dioxolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (by GC/HPLC), and identity confirmation. We adhere to cGMP principles where applicable, and our quality control protocols are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Specific Rotation [α]20/D	+15° to +20° (c=1 in CHCl3)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.