Description

25(S)-27-Hydroxy Cholesterol is a specific stereoisomer of a hydroxylated cholesterol derivative, serving as a critical biochemical intermediate and research standard. This compound is valued for its role in studying oxysterol metabolism, liver X receptor (LXR) signaling pathways, and cholesterol homeostasis. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science research sectors for drug discovery and metabolic studies.

Application

• Biochemical Research: Used as a reference standard in the study of oxysterol biosynthesis and catabolism pathways.
• Drug Discovery: Serves as a key intermediate or ligand in screening assays for Liver X Receptor (LXR) modulators targeting metabolic diseases.
• Cell Signaling Studies: Employed to investigate the role of specific oxysterols in intracellular signaling related to lipid metabolism and inflammation.
• Analytical Standard: Essential for the development and validation of analytical methods (HPLC, LC-MS) for oxysterol quantification in biological samples.
• Metabolic Disorder Research: Applied in models studying atherosclerosis, non-alcoholic fatty liver disease (NAFLD), and other cholesterol-related disorders.

Basic Information

Product Name	25(S)-27-Hydroxy Cholesterol
CAS No.	56845-83-1
Molecular Formula	C27H46O2
Molecular Weight	402.66 g/mol
Synonyms	(25S)-Cholest-5-ene-3β,27-diol; 27-Hydroxycholesterol (25S-isomer); 27(S)-Hydroxycholesterol; 5-Cholestene-3β,27-diol, (25S)-; 27-OHC (25S); 25S-27-Hydroxycholesterol; 27-Hydroxy-25S-cholesterol
EINECS	Contact for details

Quality Control

Our 25(S)-27-Hydroxy Cholesterol is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the container to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.