Description

Chloroacetonitrile, [1-14C] is a carbon-14 labeled isotopologue of chloroacetonitrile, a versatile building block in synthetic organic chemistry. This radiolabeled compound is essential for conducting detailed metabolic, pharmacokinetic, and environmental fate studies, providing critical traceability and analytical sensitivity. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and life science research sectors for advanced tracer applications.

Application

• Tracer Studies in Pharmaceutical R&D: Used as a radiolabeled intermediate to track the absorption, distribution, metabolism, and excretion (ADME) of new drug candidates and their metabolites.
• Agrochemical Research: Employed in environmental fate studies to understand the degradation pathways, soil mobility, and bioaccumulation of pesticides and herbicides.
• Metabolic Pathway Elucidation: Serves as a key tool in biochemistry for mapping complex metabolic routes and identifying novel enzymatic reactions.
• Chemical Synthesis Intermediate: Acts as a labeled precursor for the synthesis of more complex 14C-labeled compounds, including heterocycles and active pharmaceutical ingredients (APIs).
• Regulatory and Compliance Testing: Facilitates the studies required for regulatory submissions to agencies like the FDA and EPA, providing definitive data on compound fate.

Basic Information

Product Name	Chloroacetonitrile, [1-14C]
CAS No.	56746-52-2
Molecular Formula	C14CH2ClN
Molecular Weight	~76.48 g/mol (for 14C isotopologue)
Synonyms	Chloroacetonitrile-1-14C; Chloromethyl cyanide-1-14C; Monochloroacetonitrile-1-14C; 2-Chloroacetonitrile-1-14C; Cyanomethyl chloride-1-14C; [1-14C]Chloroacetonitrile; Chloroethanenitrile-1-14C
EINECS	Contact for details

Quality Control

Every batch of Chloroacetonitrile, [1-14C] is manufactured and analyzed under strict quality systems to ensure high chemical, radiochemical, and isotopic purity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specific activity, purity by HPLC, radiochemical purity, and solvent composition are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. Due to its highly volatile nature, ensure containers are securely sealed and stored in a well-ventilated, dedicated radiolabeled storage area with appropriate shielding. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 98% (Chemical Purity)
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	Contact for details (mCi/mmol)
Solvent	Typically supplied in acetonitrile or other specified solvent

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.