Description

Methyl 5-Amino-2-Fluorobenzoate is a high-purity fluorinated aromatic ester building block of significant importance in advanced organic synthesis. Its core value lies in the strategic positioning of both an amino group and a fluorine atom on the benzoate ring, enabling its use in the construction of complex molecules for pharmaceutical and agrochemical research. This compound is primarily needed by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic components in electronic materials, contributing to improved performance in display technologies.
• Dye & Pigment Intermediate: Employed in the synthesis of specialized fluorinated dyes and pigments that offer unique light-fastness and color properties.
• Cross-Coupling Reactions: The amino group facilitates further functionalization via Buchwald-Hartwig amination or other palladium-catalyzed reactions for library synthesis.
• Peptidomimetics & Bio-conjugation: Useful in medicinal chemistry for creating fluorinated analogs of peptides or for bio-conjugation linker strategies.

Basic Information

Product Name	Methyl 5-Amino-2-Fluorobenzoate
CAS No.	56741-34-5
Molecular Formula	C8H8FNO2
Molecular Weight	169.15 g/mol
Synonyms	5-Amino-2-fluorobenzoic acid methyl ester; Methyl 5-amino-2-fluorobenzoate; 2-Fluoro-5-aminobenzoic acid methyl ester; Benzoic acid, 5-amino-2-fluoro-, methyl ester; Methyl 2-fluoro-5-aminobenzoate; 5-Amino-2-fluoro methyl benzoate; Methyl (5-amino-2-fluorophenyl)carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 5-Amino-2-Fluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided to guarantee supply consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity, the container should be kept under an inert atmosphere (e.g., nitrogen) to prevent oxidation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.