Description

(S)-Viloxazine Hydrochloride CAS NO 56287-61-7 is the single enantiomer of the selective norepinephrine reuptake inhibitor viloxazine, offered as a high-purity pharmaceutical reference standard and active pharmaceutical ingredient (API) intermediate. This compound is critical for research and development focused on stereoselective pharmacology and the production of enantiomerically pure therapeutics. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and API manufacturers engaged in developing and scaling up novel central nervous system (CNS) agents.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control (HPLC, LC-MS) in pharmaceutical laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key chiral building block in the synthetic pathway for enantiomerically pure viloxazine-based drugs.
• Neurological Research: Employed in preclinical studies to investigate the specific pharmacological profile and metabolic pathways of the (S)-enantiomer.
• Process Chemistry & Scale-Up: Utilized for optimizing asymmetric synthesis routes and manufacturing processes for clinical trial material.
• Impurity Profiling: Acts as a critical marker for identifying and quantifying enantiomeric impurities in racemic viloxazine batches.
• Metabolite Synthesis: Used as a starting material for the synthesis of potential human metabolites for safety and efficacy testing.

Basic Information

Product Name	(S)-Viloxazine Hydrochloride
CAS No.	56287-61-7
Molecular Formula	C13H19NO2 • HCl
Molecular Weight	257.76 g/mol (as hydrochloride salt)
Synonyms	(S)-2-[(2-Ethoxyphenoxy)methyl]morpholine hydrochloride; (S)-Viloxazine HCl; (S)-Viloxazine monohydrochloride; (S)-Viloxazine HCL; (S)-Enantiomer of Viloxazine Hydrochloride; (S)-Viloxazine hydrochloride salt; (S)-Viloxazine chlorohydrate
EINECS	Contact for details

Quality Control

Our (S)-Viloxazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure identity, potency, and purity meet stringent specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research or cGMP intermediate requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.