Description

4-(Difluoromethyl)Benzoic Acid is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound serves as a critical intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the difluoromethyl group imparts desirable metabolic stability and bioavailability. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for creating novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in medicinal chemistry for introducing the difluoromethyl pharmacophore.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where fluorination enhances biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, altering their surface properties, chemical resistance, and stability.
• Organic Synthesis Reagent: A versatile reagent for coupling reactions and as a precursor for other difluoromethyl-substituted aromatic compounds in research and development.
• Material Science: Used in the development of advanced organic electronic materials and coatings.

Basic Information

Product Name	4-(Difluoromethyl)Benzoic Acid
CAS No.	55805-21-5
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	p-(Difluoromethyl)benzoic Acid; 4-(Difluoromethyl)benzenecarboxylic Acid; Benzoic acid, 4-(difluoromethyl)-; α,α-Difluoro-p-toluic Acid; Difluoromethylbenzoic Acid; 55805-21-5; p-Difluoromethylbenzoic Acid
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ISO 9001 standards for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	142 - 146 °C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.