Description

4-(1,1-Difluoroethyl)Benzoic Acid is a specialized fluorinated aromatic carboxylic acid building block. This compound matters for its unique difluoroethyl substituent, which imparts distinct electronic and steric properties critical for modifying molecular interactions in advanced synthesis. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly where the introduction of fluorine atoms is required to optimize potency, metabolic stability, or bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the difluoroethyl group can enhance biological activity and environmental persistence profiles.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated components for liquid crystal displays (LCDs), contributing to improved dielectric anisotropy and thermal stability.
• Polymer Modification: Incorporated as a monomer or additive to create specialty polymers with enhanced chemical resistance, lower surface energy, or specific optical properties.
• Organic Electronic Materials: Employed in the development of organic semiconductors and electron-transport materials for OLEDs and photovoltaic cells.
• Chemical Research & Development: A versatile building block in academic and industrial R&D for exploring new reactions and creating complex fluorinated molecular architectures.

Basic Information

Product Name	4-(1,1-Difluoroethyl)Benzoic Acid
CAS No.	55805-14-6
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	p-(1,1-Difluoroethyl)benzoic acid; 4-(1,1-Difluoroethyl)benzoic acid; Benzoic acid, 4-(1,1-difluoroethyl)-; α,α-Difluoro-4-ethylbenzoic acid; 4-(α,α-Difluoroethyl)benzoic acid; 1-(4-Carboxyphenyl)-1,1-difluoroethane; 55805-14-6 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 4-(1,1-Difluoroethyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance. Standard quality checks include assay (HPLC), identity confirmation (IR, NMR), and control of related substances. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. For custom synthesis or specific grade requirements (e.g., pharmaceutical intermediate grade), our technical team can tailor the quality control protocol to meet your exact project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C/59-77°F). Keep away from strong acids, bases, and oxidizing agents. Due to its nature as a strong acid/organic solvent, ensure containers are properly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.