Description

[13C5]-L-Pyroglutamic Acid CAS NO 55443-56-6 is a stable isotope-labeled analog of L-pyroglutamic acid, where five carbon atoms are replaced with the carbon-13 isotope. This high-purity labeled compound is essential for applications requiring precise quantification and metabolic pathway tracing, offering superior sensitivity and accuracy over unlabeled counterparts. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for advanced mass spectrometry, NMR spectroscopy, and clinical diagnostics.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in bioanalytical methods for drug metabolism and pharmacokinetic (DMPK) studies.
• Metabolic Pathway Tracing: Used in 13C-isotope labeling experiments to investigate glutamine and glutathione metabolism in cell cultures and animal models.
• NMR Spectroscopy: Provides a non-radioactive tracer for structural and dynamic studies of biological systems using 13C-NMR.
• Clinical Diagnostics & Biomarker Research: Enables the accurate measurement of endogenous L-pyroglutamic acid levels in physiological fluids for research into metabolic disorders.
• Pharmaceutical Impurity Profiling: Acts as a reference material in the analysis and control of related substances in peptide-based drug formulations.
• Stable Isotope-Labeled Standard (SILS) Production: A key building block for synthesizing more complex isotopically labeled peptides and biochemicals.

Basic Information

Product Name	[13C5]-L-Pyroglutamic Acid
CAS No.	55443-56-6
Molecular Formula	13C5H7NO3
Molecular Weight	~136.07 (based on 13C5)
Synonyms	(5-Oxo-L-proline-13C5); L-Pyroglutamic Acid-13C5; (S)-2-Pyrrolidone-5-carboxylic Acid-13C5; 5-Oxoproline-13C5; PCA-13C5; L-5-Pyrrolidone-2-carboxylic Acid-13C5; Glp-13C5; pGlu-13C5
EINECS	Contact for details

Quality Control

Our [13C5]-L-Pyroglutamic Acid is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research and diagnostic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity confirmation. We adhere to relevant standards for high-purity reference materials, ensuring reliable and reproducible performance in sensitive analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom % 13C
Isotopic Purity (by MS)	≥ 99% 13C5
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.