Description

7,8-Dihydro-7,8-Dihydroxybenzo(A)Pyrene 9,10-Oxide is a highly significant and reactive metabolite of the polycyclic aromatic hydrocarbon (PAH) Benzo(a)pyrene. This compound matters as a critical reference standard and research chemical for studying the mechanisms of carcinogenesis, DNA adduct formation, and metabolic activation pathways of environmental pollutants. It is essential for researchers and analytical laboratories in the fields of toxicology, environmental science, cancer research, and analytical chemistry, providing a key tool for method development, calibration, and mechanistic studies.

Application

• Toxicological Research: Used as a primary reference standard to study the metabolic activation, DNA-binding properties, and carcinogenic mechanisms of Benzo(a)pyrene.
• Biomarker Analysis: Critical for the development and validation of analytical methods (e.g., HPLC-MS, GC-MS) to detect and quantify DNA adducts in biological samples for exposure assessment.
• Environmental Monitoring: Serves as a key analyte in research focused on understanding the fate, transformation, and biological impact of polycyclic aromatic hydrocarbons (PAHs) in the environment.
• Cancer Research: Employed in *in vitro* and *in vivo* studies to investigate the initiation of chemical carcinogenesis and to evaluate chemopreventive agents.
• Analytical Standard: Provides a high-purity calibrant for ensuring accuracy and precision in chromatographic analyses within regulatory and research laboratories.
• Metabolic Pathway Studies: Utilized to elucidate the specific enzymatic pathways involved in the bioactivation of PAHs to their ultimate carcinogenic forms.

Basic Information

Product Name	7,8-Dihydro-7,8-Dihydroxybenzo(A)Pyrene 9,10-Oxide
CAS No.	55097-80-8
Molecular Formula	C₂₀H₁₄O₃
Molecular Weight	302.32 g/mol
Synonyms	BPDE; Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide; (+)-7β,8α-Dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; anti-BPDE; Benzo[a]pyrene diol epoxide; 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; 9,10-Epoxy-7,8,9,10-tetrahydro-7,8-dihydroxybenzo[a]pyrene
EINECS	Contact for details

Quality Control

Our 7,8-Dihydro-7,8-Dihydroxybenzo(A)Pyrene 9,10-Oxide is produced and handled under strict quality protocols to ensure the integrity and purity required for sensitive research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and structural verification. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided to guarantee traceability and compliance with your research or analytical standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and degradation. The container should be kept in a dry environment to prevent moisture absorption. Allow the sealed vial to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, Acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.