Description

Dapansutrile CAS NO 54863-37-5 is a small molecule pharmaceutical intermediate and research chemical with significant potential in medicinal chemistry. This compound is primarily recognized for its role as a key precursor in the synthesis of novel therapeutic agents targeting inflammatory pathways. It is of critical interest to pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in developing next-generation anti-inflammatory and immunomodulatory drugs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of NLRP3 inflammasome inhibitors for therapeutic development.
• Biochemical Research: Used in in vitro and in vivo studies to investigate inflammatory signaling pathways and immune response mechanisms.
• Preclinical Drug Development: Serves as a critical starting material or reference standard for the production of candidate drug molecules targeting conditions like gout, arthritis, and other auto-inflammatory diseases.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing specialized, high-value chemical entities.
• Reference Standard: Utilized in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.

Basic Information

Product Name	Dapansutrile
CAS No.	54863-37-5
Molecular Formula	C8H6N2O2
Molecular Weight	162.15 g/mol
Synonyms	OLT1177; β-Hydroxy Nitrile; 2-Cyano-3-hydroxy-2-butenamide; 3-Hydroxy-2-cyano-2-butenamide; 2-Butenamide, 2-cyano-3-hydroxy-; Dapansutrile (OLT1177); NLRP3 Inflammasome Inhibitor OLT1177; (Z)-2-Cyano-3-hydroxy-but-2-enamide
EINECS	Contact for details

Quality Control

Our Dapansutrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and stringent controls for residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with relevant standards for pharmaceutical intermediates. Specifications can be tailored to meet specific project requirements, including research-grade and GMP-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.