Description

Glycine, [14C(U)] CAS NO 54745-47-0 is a uniformly carbon-14 labeled isotopologue of the fundamental amino acid glycine, where all carbon atoms are the radioactive isotope 14C. This compound is essential for advanced metabolic and pharmacokinetic research, providing a critical tool for tracing biochemical pathways and studying protein synthesis and degradation. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in radiolabeling studies, drug metabolism and disposition (DMPK) research, and proteomics.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled precursor to trace the metabolic fate of glycine-containing compounds and to study absorption, distribution, metabolism, and excretion (ADME) profiles.
• Biochemical Pathway Tracing: Enables the elucidation of biosynthetic and catabolic pathways in living systems through radio-HPLC and liquid scintillation counting (LSC).
• Proteomics and Protein Turnover Research: Incorporated into proteins to study synthesis rates, half-lives, and degradation mechanisms in cell culture and animal models.
• Radiochemical Synthesis: Serves as a key building block for the synthesis of more complex carbon-14 labeled peptides, pharmaceuticals, and biochemical probes.
• Environmental and Agricultural Research: Applied in studies investigating the metabolism and environmental fate of glycine-based compounds, such as certain herbicides.
• Medical Diagnostic Research: Potential use in the development of novel radiotracers for positron emission tomography (PET) imaging, following appropriate isotopic conversion.

Basic Information

Item	Details
Product Name	Glycine, [14C(U)]
CAS No.	54745-47-0
Molecular Formula	C142H5NO2 (¹⁴C-labeled)
Molecular Weight	~77.05 g/mol (exact mass depends on specific activity)
Synonyms	[U-¹⁴C]Glycine; Glycine (U-¹⁴C); Aminoacetic acid-¹⁴C(U); ¹⁴C-Glycine; Uniformly labeled Carbon-14 Glycine; 2-Amino[U-¹⁴C]acetic acid; Glycine-¹⁴C; Radiolabeled Glycine
EINECS	Contact for details

Quality Control

Every batch of our Glycine, [14C(U)] is produced and analyzed under strict quality systems to ensure high radiochemical purity and specific activity. Quality is verified through advanced analytical techniques including HPLC with radiometric detection and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specific activity, radiochemical purity, chemical purity, and solvent composition. Our manufacturing adheres to cGMP principles suitable for research and non-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures (typically 2-8°C or as specified on the label) to maintain stability. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere if specified and opened in a controlled, dry environment. Store in accordance with local and national regulations for radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Specific Activity	Customizable (e.g., 50-120 mCi/mmol)
Radiochemical Purity (HPLC)	≥ 98%
Chemical Purity (HPLC)	≥ 95%
Solvent (for solutions)	Specified (e.g., Ethanol/Water)
Concentration	Specified (e.g., 1.0 mCi/mL ± 10%)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.