Description

Adenosine-5'-13C is a stable isotope-labeled derivative of adenosine, a fundamental nucleoside in biochemistry. This product is essential for advanced research and development, providing a critical tool for metabolic pathway tracing, quantitative analysis, and pharmacokinetic studies using mass spectrometry. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers working in drug discovery, metabolomics, and clinical diagnostics.

Application

• Internal Standard for LC-MS/MS: Serves as a quantitative reference standard in bioanalytical methods for accurate measurement of adenosine and related metabolites in complex biological matrices.
• Metabolic Flux Analysis (MFA): Used to trace and quantify carbon flow through central metabolic pathways like glycolysis, the TCA cycle, and nucleotide biosynthesis in cell culture and in vivo studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking of drug metabolites and endogenous compounds in absorption, distribution, metabolism, and excretion (ADME) studies.
• Clinical Diagnostic Assay Development: Employed in the calibration and validation of diagnostic tests measuring adenosine levels, which are biomarkers for conditions like ischemia, inflammation, and immune response.
• NMR Spectroscopy Studies: Acts as a 13C-enriched probe for structural and dynamic studies of nucleic acids and protein-nucleic acid interactions.
• Biochemical Research: Supports fundamental research into purinergic signaling, energy metabolism (ATP/ADP/AMP cycles), and the role of adenosine in neurological and cardiovascular systems.

Basic Information

Product Name	Adenosine-5'-13C
CAS No.	54447-57-3
Molecular Formula	C10H12N5O4 (with 13C at the 5' carbon position)
Molecular Weight	Contact for details
Synonyms	9-β-D-Ribofuranosyladenine-5'-13C; Adenosine-5'-13C10; 13C-Labeled Adenosine; [5'-13C]Adenosine; Adenosine (13C); Stable Isotope-Labeled Adenosine; 6-Amino-9-β-D-ribofuranosyl-9H-purine-5'-13C; Adenosine-13C (specific position)
EINECS	Contact for details

Quality Control

Our Adenosine-5'-13C is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >99 atom % 13C), chemical purity by HPLC, and identity confirmation. We support research and development requiring compliance with cGMP and ISO 9001 standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR / NMR)	Conforms to structure
Isotopic Enrichment (MS)	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.