Description

Thromboxane B2 is a stable, physiologically inactive metabolite of the potent pro-thrombotic and vasoconstrictive eicosanoid, Thromboxane A2. Its measurement serves as a critical biomarker for assessing platelet activation and thromboxane synthesis in vivo, providing invaluable insights into cardiovascular and inflammatory pathways. This compound is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and life science research sectors, particularly for developing and calibrating immunoassays, studying hemostasis, and investigating drug mechanisms related to cyclooxygenase inhibition.

Application

• Biomarker Standard for Clinical Diagnostics: Primary calibrator and reference standard in ELISA, RIA, and LC-MS/MS kits for quantifying thromboxane generation in biological samples (e.g., serum, urine).
• Pharmacological Research: Used to study the efficacy of antiplatelet drugs (e.g., aspirin, COX inhibitors) and novel compounds targeting the arachidonic acid cascade.
• Cardiovascular & Inflammation Studies: Critical tool in research models for atherosclerosis, thrombosis, and inflammatory diseases to correlate thromboxane levels with disease states.
• Quality Control in Diagnostic Manufacturing: Serves as a key raw material for the production and lot-to-lot validation of in-vitro diagnostic (IVD) devices and reagents.
• Metabolomics and Biochemical Pathway Analysis: A defined standard for mapping eicosanoid profiles and understanding lipid mediator biology in complex systems.

Basic Information

Product Name	Thromboxane B2
CAS No.	54397-85-2
Molecular Formula	C₂₀H₃₄O₆
Molecular Weight	370.48 g/mol
Synonyms	TXB2; Thromboxane B2; (5Z,13E)-(15S)-9α,11,15-Trihydroxythromboxa-5,13-dien-1-oic acid; 9α,11,15-Trihydroxythromboxa-5,13-dien-1-oic acid; 11-Dehydro-thromboxane B2 precursor; TBX2; Thromboxane B2 (solution).
EINECS	Contact for details

Quality Control

Our Thromboxane B2 is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, potency, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical: ≥ 98%)
Water Content (KF)	≤ 1.0%
Solvent Content (GC/HPLC)	As per COA (for solutions)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.