Description

12(S)-Hete CAS NO 54397-83-0 is a high-purity, stereospecific hydroxy fatty acid eicosanoid derivative, serving as a critical biochemical intermediate and research standard. Its defined stereochemistry at the 12(S) position is essential for precise biological activity studies and the synthesis of specialized lipid mediators. This compound is primarily required by research institutions and pharmaceutical developers focused on inflammation pathways, lipidomics, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a reference standard in lipidomics and eicosanoid research to study inflammation, cell signaling, and metabolic pathways.
• Pharmaceutical Development: Serves as a key intermediate or analytical standard in the R&D of anti-inflammatory drugs and other therapeutics targeting lipid mediators.
• Diagnostic Reagents: Employed in the development and calibration of enzyme immunoassays (EIAs) and other diagnostic kits for specific eicosanoids.
• Academic Studies: Utilized in university and institutional laboratories for investigating the role of specific hydroxy fatty acids in physiological and pathological processes.
• Metabolite Standard: Acts as a certified standard in mass spectrometry (LC-MS/MS, GC-MS) for the accurate quantification of related metabolites in biological samples.

Basic Information

Product Name	12(S)-Hete
CAS No.	54397-83-0
Molecular Formula	C20H32O3
Molecular Weight	320.47 g/mol
Synonyms	12(S)-HETE; 12S-HETE; (12S)-HETE; 12(S)-Hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic Acid; 12S-Hydroxyeicosatetraenoic Acid; 12(S)-HETE-d8 (deuterated analog); 12-HETE (S-isomer); 12(S)-HETE sodium salt
EINECS	Contact for details

Quality Control

Our 12(S)-Hete is manufactured under strict quality protocols to ensure high stereochemical purity and batch-to-batch consistency, critical for research reproducibility. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques. We adhere to cGMP guidelines where applicable to support our clients in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is highly volatile and moisture-sensitive; allow the vial to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or film
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95% (Area Percent)
Purity (Chiral HPLC)	≥ 98% 12(S)-isomer
Solubility	Soluble in ethanol, DMSO, and organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.